Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease.
Identifieur interne : 000C99 ( Main/Exploration ); précédent : 000C98; suivant : 000D00Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease.
Auteurs : Bogdan Neagu [Canada] ; Eric Tsang ; Filomena Mazzella ; Clement Hamani ; Elena Moro ; Mojgan Hodaie ; Andres M. Lozano ; Robert ChenSource :
- Experimental neurology [ 1090-2430 ] ; 2013.
English descriptors
- KwdEn :
- Deep Brain Stimulation, Electrodes, Implanted, Evoked Potentials (physiology), Female, Humans, Male, Middle Aged, Neural Pathways (anatomy & histology), Neural Pathways (physiology), Parkinson Disease (therapy), Pedunculopontine Tegmental Nucleus (anatomy & histology), Pedunculopontine Tegmental Nucleus (physiology), Subthalamic Nucleus (anatomy & histology), Subthalamic Nucleus (physiology).
- MESH :
- anatomy & histology : Neural Pathways, Pedunculopontine Tegmental Nucleus, Subthalamic Nucleus.
- physiology : Evoked Potentials, Neural Pathways, Pedunculopontine Tegmental Nucleus, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Male, Middle Aged.
Abstract
The effects of subthalamic nucleus (STN) stimulation on the pedunculopontine nucleus area (PPNR) evoked activities were examined in two patients with Parkinson's disease. The patients had previously undergone bilateral STN deep brain stimulation (DBS) and subsequently received unilateral DBS electrodes in the PPNR. Evoked potentials were recorded from the local field potentials (LFP) from the PPNR with STN stimulation at different frequencies and bipolar contacts. Ipsilateral and contralateral short latency (<2ms) PPNR responses were evoked from left but not from right STN stimulation. In both patients, STN stimulation evoked contralateral PPNR responses at medium latencies between 41 and 45ms. Cortical evoked potentials to single pulse STN stimulation were observed at latencies between 18 and 27ms. These results demonstrate a functional connection between the STN and the PPNR. It likely involves direct projections between the STN and PPNR or polysynaptic pathways with thalamic or cortical relays.
DOI: 10.1016/j.expneurol.2013.09.018
PubMed: 24095981
Affiliations:
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Lozano</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24095981</idno><idno type="pmid">24095981</idno><idno type="doi">10.1016/j.expneurol.2013.09.018</idno><idno type="wicri:Area/PubMed/Corpus">000831</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000831</idno><idno type="wicri:Area/PubMed/Curation">000831</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000831</idno><idno type="wicri:Area/PubMed/Checkpoint">000831</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000831</idno><idno type="wicri:Area/Ncbi/Merge">001581</idno><idno type="wicri:Area/Ncbi/Curation">001581</idno><idno type="wicri:Area/Ncbi/Checkpoint">001581</idno><idno type="wicri:Area/Main/Merge">000D08</idno><idno type="wicri:Area/Main/Curation">000C99</idno><idno type="wicri:Area/Main/Exploration">000C99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease.</title><author><name sortKey="Neagu, Bogdan" sort="Neagu, Bogdan" uniqKey="Neagu B" first="Bogdan" last="Neagu">Bogdan Neagu</name><affiliation wicri:level="4"><nlm:affiliation>Toronto Western Research Institute, University Health Network, University of Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, University of Toronto</wicri:regionArea><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Tsang, Eric" sort="Tsang, Eric" uniqKey="Tsang E" first="Eric" last="Tsang">Eric Tsang</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></analytic><series><title level="j">Experimental neurology</title><idno type="eISSN">1090-2430</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neural Pathways (anatomy & histology)</term><term>Neural Pathways (physiology)</term><term>Parkinson Disease (therapy)</term><term>Pedunculopontine Tegmental Nucleus (anatomy & histology)</term><term>Pedunculopontine Tegmental Nucleus (physiology)</term><term>Subthalamic Nucleus (anatomy & histology)</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Neural Pathways</term><term>Pedunculopontine Tegmental Nucleus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials</term><term>Neural Pathways</term><term>Pedunculopontine Tegmental Nucleus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of subthalamic nucleus (STN) stimulation on the pedunculopontine nucleus area (PPNR) evoked activities were examined in two patients with Parkinson's disease. The patients had previously undergone bilateral STN deep brain stimulation (DBS) and subsequently received unilateral DBS electrodes in the PPNR. Evoked potentials were recorded from the local field potentials (LFP) from the PPNR with STN stimulation at different frequencies and bipolar contacts. Ipsilateral and contralateral short latency (<2ms) PPNR responses were evoked from left but not from right STN stimulation. In both patients, STN stimulation evoked contralateral PPNR responses at medium latencies between 41 and 45ms. Cortical evoked potentials to single pulse STN stimulation were observed at latencies between 18 and 27ms. These results demonstrate a functional connection between the STN and the PPNR. It likely involves direct projections between the STN and PPNR or polysynaptic pathways with thalamic or cortical relays.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Tsang, Eric" sort="Tsang, Eric" uniqKey="Tsang E" first="Eric" last="Tsang">Eric Tsang</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Neagu, Bogdan" sort="Neagu, Bogdan" uniqKey="Neagu B" first="Bogdan" last="Neagu">Bogdan Neagu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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